Reproductive epidemiology

Postpartum Hemorrhage As a Marker of Cancer

Abstract The association between carcinogenesis and subsequent bleeding is established. We investigated whether postpartum hemorrhage (PPH) may be a marker of clinically unrecognized cancer in women of reproductive age. In the full population, 51 224 women comprised the PPH cohort, and 536 016 women comprised the comparison cohort.

Threatened abortion and risk of epilepsy, cerebral palsy and attention-deficit/hyperactivity disorder (ADHD) in children

Abstract Previous research revealed that children born from threatened abortion (TAB)-affected gestation are at 2-3 fold increased risk of autism spectrum disorders and developmental coordination disorder. In conventional cohort analysis, TAB-affected children had a 21-25% higher relative risk of epilepsy, attention-deficit/hyperactivity disorder (ADHD), in the first 16 years of life and 42% higher relative risk of cerebral palsy in the first 6 years of life.

Hypertensive disorders of pregnancy and utilization of antihypertensive therapies

Background Hypertensive disorders of pregnancy are associated with mortality and morbidity in offspring and mothers. Use of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) is contra indicated in pregnancy.

Hypertensive Disorders Of Pregnancy And Utilization Of Antihypertensive Therapies

LACEi or ARBs were dispensed in pregnancies with chronic hypertension (590/735, 80.3%), preeclampsia superimposed on chronic hypertension (130/735, 17.7%), and gestational hypertension (15/735, 2.0%). The utilization of ACEi or ARBs for therapy of HDP was low, but not absent.

Vaginal bleeding in early pregnancy and risk of occult cancer

Vaginal bleeding in early pregnancy is not associated with a higher cancer risk compared with pregnancies in women from the general population of similar age.

Threatened abortion and risk of cancer

We identified 105,277 women with threatened abortion (TA), with a median follow-up of 16.9 years (interquartile range 10.5-24.4 years). During the follow-up, 6,571 women with TA developed cancer. The standardised incidence ratio (SIR) for any cancer was 1.01 (95% CI=0.98-1.03). TA was not associated with an increased risk of cancer of breast (SIR=1.02, 95% CI=0.98-1.07), uterine cervix (SIR=0.93, 95% CI=0.83-1.03), ovary (SIR=0.91, 95% CI=0.78-1.06); or uterus (SIR=0.79, 95% CI=0.66-0.95). TA is not associated with an increased risk of cancer diagnosis.

Threatened abortion and risk of cancer

Abstract The objective of the study was to investigate an association between TA and the woman’s subsequent increased risk of cancer. We conducted a nationwide cohort study of 105,277 women with a first-time threatened abortion (TA) diagnosis in Denmark (1978-2013) with up to 33 years of follow-up.