Vaginal bleeding in early pregnancy and risk of occult cancer

Abstract

We identified 105 192 women in the vaginal bleeding (VB) cohort. Median age at VB diagnosis was 28.7 years (interquartile range = 25.2–32.5 years) and median follow-up was 17.0 years (interquartile range = 10.5–24.4 years). During the follow-up, 6581 women in the VB cohort received a cancer diagnosis. The SIR for any cancer was 1.02 (95% CI=0.99–1.04). VB was not associated with an increased risk of cancer during <6 months (SIR=0.88, 95% CI=0.65–1.18), 6–12 months (SIR=0.81, 95% CI=0.59– 1.08), or > 12 months (SIR=1.02, 95% CI=0.99–1.04) of follow-up. VB did not increase risk of cancer of the breast (SIR=1.02, 95% CI=0.98–1.07), uterine cervix (SIR=0.92, 95% CI=0.83–1.02), ovary (SIR=1.04, 95% CI=0.89–1.21), or uterus (SIR=0.94, 95% CI=0.78–1.12).